Starting date : Jan. 2018 > Jun. 2021
Lifetime: 42 months
Program in support : H2020-NMBP-PILOTS-2017
Status project : in progress
CEA-Leti's contact :
Raphaël Trouillon
Project Coordinator: CIDETEC-IK4 Research Alliance (ES)
Partners: - BE: Coris BioConcept
- DE: Securetec Detektions-Systeme, Varta
- ES: Biolan Microbiosensores, Cidetec-IK4, Guarro Casas, Scienseed
- FI: Aalto University, Spinverse, VTT
- FR: AMU (Université d’Aix Marseille), CEA (Leti, Liten), Vertech-Group
- NO: Skanem
- PT: YD Ynvisible
Target market: n/a
Publications:
«Two-Dimensional Antifouling Fluidic Channels on
Nanopapers for Biosensing», K. Solin, H. Orelma,
M. Borghei, M. Vuoriluoto, R. Koivunen, and O. J. Rojas,
Biomacromolecules, DOI: 10.1021/acs.biomac.8b01656.
Investment: € 7.4 m.
EC Contribution: € 7.4 m.
| Stakes
Design and development of a paper-based electrochemical genosensors that integrate sample preparation, DNA amplification and DNA detection into one system to be used in streptococcus bacteria and influenza virus detection in saliva, nasal specimens and throat swabs. • Fabrication of a microfluidic, electrochemical, paper-based Analytical Device (μePAD): > Designing a microfluidic paper technology compatible with LAMP amplification > Printing of reference and operating DNA electrodes at top of custom paper-based chamber > Optimizing the printing process (inks, mesh characteristics and printing parameters) for the plastic, electrochemical genosensor to produce a well-defined, reproducible μePAD for DNA amplification and detection using INNPAPER paper. • Modification of μePADs using bioreagents: > Developing specific reagents and bioreagents for sample pretreatment, DNA amplification and DNA detection. Establishing sample pretreatment protocols and modifying the microfluidic channel in one zone (sample pretreatment) using reagents for sample dilution and DNA extraction > Modifying the paper-based LAMP chamber using bioreagents (primers) for DNA amplification > Optimizing all parameters involving sample pretreatment, LAMP, amplification and DNA detection (type/quantity of bioreagents). • Application of new paper-based electrochemical genosensors to streptococcus bacteria and influenza virus detection: > Comparing results with those obtained using official method (e.g. quantitative PCR) > Integrating paper-based electrochemical genosensors into common platform to produce the final integrated PoC genetic assay.
Flexible, easily foldable and recyclable paper, used as a substrate and functional part of portable, wireless and/or disposable electronic devices, is emerging as a promising material for developing sustainable electronic components that generate less waste. INNPAPER is a use case-driven project that provides a configurable common electronic platform based on multifunctional paper. The project is developing innovative approaches to paper manufacturing, including (Nano) cellulose functionalization, to produce paper with custom properties ((super)hydrophobicity/philicity, conductivity, etc.) at surface and body levels. A configurable common platform featuring a variety of paper-based devices (printed battery, electrochromic display, antenna and hybrid electronic circuit) is being developed on which paper will act as substrate and active component. This common platform underpins manufacturing of several use cases in different industrial sectors, especially packaging and Point of Care (PoC) assays (security, food traceability, and medical). The paper-based platforms are fabricated on existing pilot printing and hybrid production lines at the project partners’ facilities. This is creating a business case involving not only a high impact paper-based electronics, but also an open-access pilot line network for the EU. An eco-design strategy, including sustainability and re-use considerations, is being implemented. An operation and business plan is being drawn up to ensure the short- and long-term profitability of the pilot lines as well as commercialization of resulting paper-based platforms. Achieving INNPAPER targets supports EU industry in the emerging Internet of Things and consolidates paper making and wood harvesting industries as well as the EU’s position environmental management of electronic waste.
IMPACT
A new disruptive, sustainable, paper-based electronics platform, which not only integrates discrete devices, but also uses cellulose as an electronic material for insulators, electrolytes, conductors and semiconductors.
Use of same paper substrate used to support electronics to drive ECDs, communication systems, PoC bioplatforms and smart labels, based on an embedded chemical battery power source.
Reduction of the environmental impact of electronics.
|
|